Direct Reprogramming—The Future of Cardiac Regeneration?
نویسندگان
چکیده
منابع مشابه
Direct Reprogramming—The Future of Cardiac Regeneration?
Today, the only available curative therapy for end stage congestive heart failure (CHF) is heart transplantation. This therapeutic option is strongly limited by declining numbers of available donor hearts and by restricted long-term performance of the transplanted graft. The disastrous prognosis for CHF with its restricted therapeutic options has led scientists to develop different concepts of ...
متن کاملDirect Cardiac Reprogramming: Advances in Cardiac Regeneration
Heart disease is one of the lead causes of death worldwide. Many forms of heart disease, including myocardial infarction and pressure-loading cardiomyopathies, result in irreversible cardiomyocyte death. Activated fibroblasts respond to cardiac injury by forming scar tissue, but ultimately this response fails to restore cardiac function. Unfortunately, the human heart has little regenerative ab...
متن کاملDirect reprogramming for cardiac regeneration: from dream to reality.
Direct reprogramming of endogenous fibroblasts into functional cardiomyocytes to regenerate the heart after myocardial infarction (MI) has long been a dream. A few years ago, this would have been considered by most to be science fiction. Certainly, the most optimistic scientists would probably categorize this as “highly unlikely to ever work.” And yet, 2 papers,1,2 including one in this issue o...
متن کاملBioluminescence imaging: a shining future for cardiac regeneration
Advances in bioanalytical techniques have become crucial for both basic research and medical practice. One example, bioluminescence imaging (BLI), is based on the application of natural reactants with light-emitting capabilities (photoproteins and luciferases) isolated from a widespread group of organisms. The main challenges in cardiac regeneration remain unresolved, but a vast number of studi...
متن کاملcardiac biomarkers: a focus on cardiac regeneration
historically, biomarkers have been used in two major ways to maintain and improve better health status: first, for diagnostic purposes, and second, as specific targets to treat various diseases. a new era in treatment and even cure for the some diseases using reprograming of somatic cells is about to be born. in this approach, scientists are successfully taking human skin cells (previously co...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2015
ISSN: 1422-0067
DOI: 10.3390/ijms160817368